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To understand if acetylation of Rheb at K151 has any role in GDP release from Rheb, we performed pulling force simulations to investigate the GDP binding strength in Rheb WT, Rheb K151acetylated, and mutants (K151R, K151Q)
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Given the compounds increasing availability, popularity, and its regulatory controversies, we sought to assess the breadth and quality of preclinical and clinical data supporting its use in musculoskeletal medicine
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