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Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation
Food supplement: Sulphur-containing foods (broccoli, garlic, onions, spinach and avocados) are known to elevate the natural level of glutathione
10.1210/jc.2018-1204 J
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