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If a pen freezes, it can no longer be used Room-temperature storage (up to 21 days) There will be times when refrigeration isnt possible
Medications for nausea, acid reflux, and pain may have altered bioavailability when taken simultaneously with tirzepatide
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Of the older therapies, sulphonylureas, insulin and glitazones are all associated with significant weight gain, whereas metformin is associated with slight weight loss
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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