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Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects

Those with a faster metabolism or severe deficiency might notice the benefits waning more quickly, typically within one to two weeks, especially regarding the energy-boosting effects

There are clinical trials evaluating if these GLP-1 and multi-agonists can address neurodegeneration, addiction, inflammation, and beyond

For example, one might see that the nausea always peaks 48 hours after an injection, or that energy crashes happen when skipping protein targets for three days in a row