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Specifically, DJ-1 preserves the activity of S-adenosylhomocysteine hydrolase (SAHH), the key enzyme that hydrolyzes S-adenosylhomocysteine (SAH) to homocysteine within this metabolic cascade
This observation likely reflects that MIA-induced OA primarily targets cartilage, whereas changes of the subchondral bone occur secondarily and can be influenced by factors such as mechanical loading, individual variability, and baseline bone status 52
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