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10-14 The Diabetes Control and Complications Trial demonstrated a relationship between improved blood glucose control and increased risk of early worsening of DR, as well as between long-term risk reduction of DR with sustained blood glucose improvement

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arginine 3) works by binding to IGF-1 receptors located on muscle satellite cells, initiating signalling pathways that drive protein synthesis while inhibiting protein breakdown