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When older individuals have been studied, analyses from trials such as Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) suggested that more frail individuals have worse outcomes and benefit less from intensive control of blood glucose levels and blood pressure [263]
Starting with a lower dose and gradually titrating upward can help minimize nausea and enhance tolerability
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Some research suggests it may be as effective as low-dose antibiotics for preventing recurrent UTIs in susceptible individuals
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