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Overall, strategies leading to downregulation of the receptor, and not only inhibition of its TK activity, have been associated with the strongest antitumour efficacies (Baserga et al, 2003)
Perhaps the most impressive finding involved a composite endpoint: achieving HbA1c at or below 6.5% with at least 10% body weight loss and no hypoglycemic episodes
It is a lab-made peptide that behaves as a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors
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