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However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect ( 2 complex with platinum drugs

Limited Western replication

In experimental models, body weight gains have been observed, possibly connected to both food intake regulation and hormonal influences independent of growth hormone

on the contrary, it is dispersed heterogeneously, mainly as single cells, along the epithelium of the GI tract, from the stomach to the rectum with a defined cephalocaudal, crypt-to-villus in the small intestine and crypt-to-surface distribution in the colon ( Despite representing just 1% of the adult gut epithelium, in the last decade it has become clear that the EECs constitute the largest endocrine organ in mammalia ( Collectively, the EECs are responsible for the production of more than 30 different hormones that help to orchestrate the fate of the intermediary metabolism