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Chronic insult of the free radicals leads to impairment of antioxidant defense and decreases endogenous antioxidant activity such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) 10,11

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[sources 7] These findings were subsequently corroborated by a 2022 meta-analysis that sampled nearly four million participants, which found no association between therapeutic use of amphetamine and the development of cardiovascular disease in any age group

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Ann Intern Med 1985;103:68-9

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