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The co-primary endpoints of the study at 72 weeks were the percentage change in weight from baseline and a body weight reduction of 5% or more (82)

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Inhibition of either PI3K or mTOR abolished accumulation of HIF-1 triggered by Exendin-4, suggesting that such event occurs downstream of mTOR (Fig

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doi.org/10.1056/NEJMoa2032183 Medically Reviewed by Karla K

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February 21, 2024

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