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Clinical Evidence Human Trials: A randomized, placebo-controlled study in obese adults demonstrated that AOD-9604 significantly reduced abdominal and total body fat over several weeks of treatment, without serious side effects Animal Studies: Preclinical studies in mice and rats showed that AOD-9604: Stimulated lipolysis Inhibited lipogenesis (formation of new fat) Prevented weight gain despite high-fat diets This dual actionenhancing fat breakdown and inhibiting fat formationpositions AOD-9604 as a potent tool for combating obesity

They are subsequently degraded in the proteasome and translocated into the nucleus where they bind to specific DNA sequences and initiate the transcription of target genes involved in the immune response, inflammation (e.g., tumor necrosis factor (TNF)-, ILs 1 and 6, prostaglandins), chemotaxis (e.g., IL-8), cell adhesion (intercellular adhesion molecule-1, vascular adhesion molecule-1), growth regulation, and apoptosis resistance

1 2 European Food Safety Authority (25 September 2008)

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