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Key Takeaways Retatrutide is not FDA approved as of May 2026
SIRVA isnt a medical diagnosis so much as it is a medical-legal description
Some patients will use Wegovy until they reach their weight loss goal and then switch to maintenance therapy, others will stay on a long term to maintain weight loss
The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes
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