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As such, they have emerged as a powerful platform for investigating the molecular mechanisms underlying cancer drug resistance
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At the fifteenth position, histidine is substituted with alanine
We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41
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