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Oxidative stress is another factor that can damage reproductive health
However, the possibility of IGF-I to influence neural stem cells (NSC) is still on debate despite the fact that IGF-I and IGF-IR are expressed in cultured NSC[60, 61], and that in response to IGF-I, cultured NSC proceed toward specific lineages, such as neurons[62] or oligodendrocytes[63]
In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment
And reduction rate between (-5.6,-6.7 mm Hg) in a 26 week study of liraglutide in combination with Metformin and Rosiglitazone compared to (-1.1 mm Hg)placebo and also with no difference in diastolic blood pressure [12]
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