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The FDA has issued explicit warnings about unapproved GLP-1 drugs, including retatrutide, being sold as research use only products often with dosing instructions clearly intended for human use

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It enhances the expression of growth hormone receptors and is mainly responsible for muscle, injury, and tendon healing, and activating angiogenesis

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care