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14-16 For patients receiving either a GLP-1 RA or an SGLT2 inhibitor for CV risk reduction, the ADA recommends considering the addition of the other class if benefits outweigh risks (e.g., if already on a GLP-1 RA, add an SGLT2 inhibitor with proven CV benefit or vice versa) in addition to optimizing other guideline-directed medical therapies for prevention ( Figure 4 )
These changes can sometimes lead to changes in how urine looks or smells
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