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Mechanism of Action 5-Amino-1MQ acts as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue, liver, and certain metabolically active cells
However, they also lead to proliferation of minor, rare, resistant cell subclones, increasing the heterogeneity
The only structural difference is the first amino acid: glycine vs alanine
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