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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118
A possible role for duloxetine in prevention of CIPN was suggested by a double-blind randomized trial in 47 patients with breast cancer receiving paclitaxel chemotherapy
Chemosphere 185:11441156
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