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Free radicals often stem from chronic inflammation, autoimmune disorders, or exposure to pollutants
The first human safety study on health volunteers was conducted in 2002 and a phase 2 double blind, randomized clinical trial (small and not sufficient for US phase 2 purposes) was conducted in 2005 with BPC-157 enemas for ulcerative colitis, with some promising effects (see research name PL 14736 to find the references)
Upon reperfusion, the abrupt ROS burst and the release of DAMPs recruit circulating monocytes and promote their differentiation into pro-inflammatory M1 macrophages
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