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Diabetes Metab J
Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice
doi: 10.1002/art.40128 182 ChooQYHoPCTanakaYLinHS
(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug
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