These modifications in metabolism pathways resulted in a substantial increase in the levels of 48 metabolites such as Xanthine, ascorbate, Cys-Gly, kynurenine, phenylalanine, 5-hydroxykynurenine, and others as outlined in Supplementary Figures 5A, B
by contrast, 100 mg/kg resulted in epithelial collapse, germ cell apoptosis, abnormal sperm morphology, and LDH elevation, with only partial recovery by week 10, as reported by Prasad et al., 2010a, Prasad et al., 2010b, Prasad et al., 2011 (12, 17, 18)
2.2.2 Amino acid metabolism Mounting studies indicate that cystine uptake via System Xc is crucial for maintaining glutathione (GSH) levels and inhibiting ferroptosis (Yang et al., 2014)
Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: a long and winding road