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5-Amino-1MQ was developed as a research tool to selectively block NNMT in vitro and in vivo, primarily by the Watowich group at the University of Texas at Austin
The strongest reproducible mechanism finding in the T4 literature is 1:1 binding of monomeric ATP-G-actin via the LKKTET motif at residues 17-22, with affinity in the sub-micromolar range (Safer 1991) [3]
PMC 4545890
What it does not do is settle how well BPC-157 works, or for whom
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