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In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain
Taking smaller meals, staying hydrated, and gradually increasing your fiber intake can make side effects easier to manage
This practice is not contradicted by the trial data
Tirzepatide side effects Reported effects and how often they occurred
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