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Avoid drinking too much alcohol
This transgenic mouse overexpresses the human amyloid precursor protein (APP) carrying two familial AD mutations: The Swedish mutation (KM670/671NL), which increases total A production by enhancing -secretase cleavage, and the Indiana mutation (V717F), which alters -secretase cleavage to favor production of the more aggregation-prone amyloid-beta 142 peptide (A 142 ) [464467]
Questions and Answers: Benzyl alcohol in the context of revision of the guideline on excipients in the label and package leaflet of medicinal products for human use
En resumen, la investigacin preclnica sugiere un margen de seguridad amplio en animales, pero no equivale a una demostracin de seguridad en humanos
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