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The cohort was too small to analyse the effectiveness in subgroups of different aethiopathologies
When L-arginine is converted to nitric oxide, L-citrulline is produced as a byproduct ( L-citrulline can then be recycled back to L-arginine and used to increase your bodys natural production of nitric oxide
For all new drugs, a thorough safety profile needs to be established, with particular emphasis on cardiovascular safety
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