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In addition to NO scavenging by oxyhemoglobin, further studies have demonstrated that erythrocytes can also store and release NO in hypoxic conditions [46]
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When the brain is exposed to a certain degree of oxidative stress, glial cells can cause neuronal damage, but also secrete a large amount of neuropeptides to protect both glial cells and neurons, and improve the brains defense against oxidative stress (Toledano et al., 2016), so the protection of glial cells can be considered directly related to nervous system protection
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