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These modifications extended the half-life from 2 minutes to 7 days, making once-weekly dosing feasible

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Hormonal regulation of metabolism: the role of enteroendocrine cells and incretins Metabolic regulation is tightly controlled by a complex network of hormones, many of which are secreted by enteroendocrine cells (EECs) , specialized sensory cells that make up about 1% of the gut epithelium

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