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Fragment 108 binds to the region known as the doorstop pocket, located near the NADPH binding site, joining four previously identified fragments: F-64 , F-68 , F-90 , and F-117
The ferroptosis inducer erastin irreversibly inhibits system x(c)- and synergizes with cisplatin to increase cisplatins cytotoxicity in cancer cells
This work was also supported by a grant from the Italian Ministry of University and Research (PRIN2017-201779W93T) to FC and from MIUR Progetto Eccellenza (2018-2022) to the Department of Pharmacological and Biomolecular Sciences, Universit degli Studi di Milano, Milan, Italy
In another experiment, TT with Nardostachys jatamansi DC
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