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a phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated significant weight reduction in adults with obesity, and further trials are ongoing (see ClinicalTrials.gov for current study identifiers)
Why Semaglutide Is Not Recommended During Pregnancy There is limited data in humans, but animal studies have shown potential risks
This LRRK2-ferroptosis interaction creates a pathogenic loop: ferroptosis-induced ROS is known to upregulate LRRK2 kinase activity, and the activated LRRK2 further promotes the phosphorylation of -synuclein at Ser129, which is believed to increase its neurotoxicity (Derry et al., 2020)
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