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Notably, five overexpressed GST isozymes reduced the typical accumulation of ROS, which suggested that these isozymes could glutathionylate ROS-generating enzymes with GSH, thus inhibiting superoxide and hydrogen peroxide in both mitochondria and the cytoplasm [50]

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Step one: lifestyle and metformin For most patients with newly diagnosed Type 2 diabetes, the first-line treatment is lifestyle modification (diet, exercise, weight management) combined with metformin, an oral medication that reduces liver glucose production and improves insulin sensitivity