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The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

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Each time a cell divides, the DNA replication machinery cannot fully copy the very end of a linear chromosome a problem called the end replication problem resulting in the loss of 50-200 base pairs of telomeric DNA per division

Thus, the authors state that TB4 may be capable of re-activating embryonic processes.29 December 2021 review A 2021 review covers the results of a few human TB4 trials