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SNP-specific F-statistics were calculated to evaluate the instrumental efficiency of SNPs with R 2 , exposure sample size, and the number of SNPs (Supplementary Table S1) ( Statistical analysis An inverse-variance weighted (IVW) analytical approach was applied to provide MR estimation and showed the largest statistical power among all MR methods by combining each Wald ratio of multiple SNPs ( 0
Increased production of melanin leads to darkening of the skin, known as hyperpigmentation
These symptoms are characteristic of infectious or inflammatory conditions affecting the pharynx and are not part of tirzepatide's known adverse effect profile
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