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Regarding the mechanisms of crossing the nasopharyngeal barrier, a combination of transcellular and paracellular pathways seems possible if meningococci using the transcellular pathway induce a sufficient level of inflammation to alter epithelial permeability, allowing other meningococci to follow the paracellular pathway
In OA, however, due to an inflammatory microenvironment and cellular stress, glycolytic flux often becomes further elevated to meet energy demands, while mitochondrial dysfunction may reduce oxidative phosphorylation efficiency (100)
[PMID: 37950798] Laboratory literature summary: Potential New investigational Implications of Semaglutide: New Colours of the Rainbow
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