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They are potent activators of the nuclear receptor peroxisome proliferator-activated receptor (PPAR), which is most enriched in adipose tissue and plays a critical role in adipocyte differentiation, lipid and glucose metabolism, and anti-inflammation

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In these people, birth control pill levels were unaffected

In a completed phase 2b, randomized, double-blind, placebo-controlled trial 19 , we tested whether once-weekly semaglutide can slow epigenetic aging in PWH-associated lipohypertrophy, a population marked by visceral adiposity and accelerated epigenetic age