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Retatrutide may require particular caution or may not be suitable for individuals with: A personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) based on findings in rodent studies, this is a precaution shared across the GLP-1 receptor agonist class in EU and UK product information
Rebound hunger: As the appetite-suppression effects fade (usually noticeable 1-2 weeks after the last dose), many people experience "food noise" returning
Biotechnol J 7:566568
While these medications can be highly effective for managing conditions like MASLD, diabetes, and metabolic conditions associated with being in a larger body, they are not without risks
