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Kim SH, Saba E, Kim BK, Yang WK, Park YC, Shin HJ, et al

Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28

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Confocal microscopy revealed a significant reduction in the colocalization of astrocytes with the cerebral cortex and hippocampal vessels in the HFD SAL group