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Critically, subsequent metagenomic analysis revealed that LEO (60 mg/kg) effectively reversed diabetes-associated dysbiosis, evidenced by a marked increase in -diversity (Shannon index), elevated relative abundance of Firmicutes, and specific enrichment of butyrate-producing genera such as Alistipes (Figures 3BE)
The SELECT trial (The New England Journal of Medicine, 2023) studied over 17,600 adults aged 45 and older with overweight or obesity and established cardiovascular disease but not diabetes
Thier R, Pemble SE, Kramer H, Taylor JB, Guengerich FP, Ketterer B
That caution is the point
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