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Each of these enzymes plays a role in detoxifying cytotoxic reactive oxygen species, such as hydrogen peroxide, which are rapidly accumulated in response to stress such as exposure to xenobiotic metabolites 58
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As detailed in Sections 3.1.13.1.4, specific probiotic genera, such as Bifidobacterium , Lactobacillus and Akkermansia muciniphila , exert protective effects against RE through defined mechanisms, including barrier reinforcement, immunomodulation, and the promotion of epithelial regeneration
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