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Research suggests GIP activation improves insulin sensitivity in adipose tissue, may contribute to central nervous system appetite regulation beyond what GLP-1 provides, and appears to reduce some of the gastrointestinal side effects associated with GLP-1 agonism alone
Serious effects are uncommon and mainly linked to unregulated, high-dose, or non-sterile use
Nature 585 , 288292 (2020)
Real-world data confirms these results persist when patients maintain medication use and lifestyle modifications
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