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Cells under chronic ferroptotic stress exhibited increased sensitivity not only to the ferroptosis inducer RSL-3 but also to hydrogen peroxide
Glutathione is produced by the liver and is involved in many body processes
In a phase I trial of CB-839 in relapsed leukemia, patients receiving CB-839 treatment usually showed grade 1 or 2 toxicities like transaminitis, thrombocytopenia, gastrointestinal events, and fatigue and about 1/3 (9/26) patients showed grade 3 or 4 toxicities like hematologic cytopenia [63]
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