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Clinical trials would need to assess both hemodynamic parameters and clinical outcomes including walking distance, pain scores, and amputation rates to establish therapeutic benefit

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Design of potent peptide mimetics of brain-derived neurotrophic factor

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However, the two orientations of KA, which are demonstrated by crystallography and in silico simulations (Figs 3 and 4), support the mixed inhibition mechanism, which is confirmed by our kinetic experiments (Fig

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