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C ssmin = (C -48h + C -24h + C 0h )/3

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In another study, the percent bone volume (BV/TV) and trabecular number (Tb.N) were lowered in diabetic and insulin-resistant (IR) rats, while their trabecular separation (Tb.Sp), trabecular bone pattern factor (Tb.Pf), and structure model index increased, indicating an elevated level of anisotropy in trabecular bone and destruction of the normal bone structure

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