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In sum, ongoing and future research will define the best pediatric dosing regimens, clarify which patients derive maximal benefit, and ensure that the long-term efficacy and safety of GLP-1 RAs in youth are fully understood
In a small randomized, double-blind, placebo-controlled, crossover trial, LEAP2 infusion reduced postprandial glucose excursions, growth hormone concentrations and ad libitum food intake in healthy men (130)
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The corresponding placebo-group changes were small. The pooled Phase 3 analysis included more than 800 participants and confirmed a significant treatment effect on visceral adipose tissue. These results formed the basis of tesamorelins FDA-approved prescription indication
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