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It gets into circulation, where it can reach follicles from the blood supply as well as exert broader systemic effects
2 Methods An umbrella review is used to synthesize and evaluate evidence from existing systematic reviews and meta-analyses, providing a comprehensive and holistic understanding of an issue and the highest level of evidence ( 2.1 Search strategy References for this review were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for related studies from the inception to September 30, 2025
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