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Effects on skeletal muscle fibers, amino acid uptake, and protein synthesis IGF-1 LR3 has been shown to have a variety of effects on skeletal muscle fibers, including increased size and number of myofibrils (the contractile units within muscle cells), as well as improved sarcomere organization (the structural units within myofibrils)

Surgical management is indicated for progressive scoliosis or progressive joint pain not responsive to non-operative management

Peer review Peer review information Communications Biology thanks the anonymous reviewers for their contribution to the peer review of this work

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