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The three hormones involved are: GLP-1, which helps slow digestion and reduce appetite GIP, which supports insulin release and influences how full you feel Glucagon, which plays a role in blood sugar balance and fat metabolism Medicines that act on all three pathways are also known as triple hormone agonist medications
17 These adverse effects can be attributed to either direct gastrointestinal and bone marrow toxicity, mediated by folate antagonism, with symptoms such as nausea, vomiting, abdominal discomfort, oral mucositis and myelosuppression, or due to idiosyncratic or allergic reactions like pneumonitis
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