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The combo runs in a structured cycle with a built-in dose increase at Month 2
This may continue for several weeks or even months, as neurological recovery is often slower and more variable than haematological response
[17] [18] Patients should report persistent upper abdominal pain to their clinician
The main role of folates in decreasing plasma levels of homocysteine might be explained merely by the fact that, in contrast to 5-methylTHF, cobalamin and pyridoxal-5-phosphate only act as cofactors and are not consumed during homocysteine processing (Durand et al, 1998a
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