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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
Find out which types of supplements are most likely to cause adverse effects such as nausea, dizziness, racing heart, or insomnia based on a study of supplement users
The overall quality of evidence for this outcome was low due to serious imprecision (low number of trials and participants)
Seek medical evaluation if symptoms are rapidly worsening, affecting balance or walking, involving weakness, or not improving after several weeks of supplementation
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