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Without a clear baseline, it is hard to know whether the added compound changed anything
In the SURPASS-2 trial, tirzepatide 15 mg was superior to semaglutide 1 mg for HbA1c reduction, with up to 46% of patients achieving near-normoglycemia (HbA1c below 5.7%)
Exendin-4-based agents (exenatide and lixisenatide) appear to carry the highest reported risk of hypersensitivity reactions, attributable to their non-human structural origin
The Retatrutide version of this logic is a direct extension of that same principle
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